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Related Experiment Videos

Disseminated necrotizing leukoencephalopathy.

Y Nakazato, Y Ishida, M Morimatsu

    Acta Pathologica Japonica
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Intrathecal chemotherapy with methotrexate and cytosine arabinoside for chronic myelogenous leukemia caused severe neurological damage. Autopsy revealed demyelination and necrosis in the brain, linked to methotrexate toxicity.

    Area of Science:

    • Neuropathology
    • Neuro-oncology

    Background:

    • A patient with chronic myelogenous leukemia (CML) received intrathecal chemotherapy due to meningeal infiltration.
    • The treatment involved methotrexate and cytosine arabinoside administered directly into the cerebrospinal fluid.

    Observation:

    • The patient developed neurological signs indicating bilateral cerebral dysfunction.
    • Progressive neurological deterioration led to the patient's death.

    Findings:

    • Neuropathological examination revealed multiple, disseminated areas of demyelination and coagulative necrosis in the cerebral white matter.
    • Key findings included decreased glial nuclei, mineral salt deposits, axonal swellings, moderate astrocytosis, and mild status spongiosus.

    Implications:

    Related Experiment Videos

  • The observed neuropathological changes suggest a potential toxic effect of intrathecal methotrexate.
  • This case highlights the critical need to monitor for and understand the neurological complications associated with intrathecal chemotherapy in CML patients.