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Updated: Aug 17, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Proteinuria in D-penicillamine-treated rheumatoid arthritis
Abstract:
The incidence of proteinuria in D-penicillamine-treated rheumatoid arthritis has been between 10% and 20% in the 1st year of therapy; afterward, few develop proteinuria. Incidence is related to both quantity of penicillamine administered and inherent response variability. About 1/3 of those with proteinuria may proceed to a nephrotic syndrome if therapy is continued. Light microscopy of renal biopsy tissue shows only minimal glomerular changes. Electron microscopy reveals sub-epithelial electron-dense deposits and fusion of epithelial cell processes. Immunofluorescence microscopy demonstrates granular capillary wall deposits of IgG and C3.
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