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Sciatica in CGL: a sign of transformation
Clinical and Laboratory Haematology
|January 1, 1981
Summary
Sciatica and back pain in chronic granulocytic leukemia patients may indicate disease acceleration. This symptom can herald the terminal stage, with all studied patients eventually succumbing to the illness.
Area of Science:
- Hematology
- Oncology
- Neurology
Background:
- Chronic granulocytic leukemia (CGL) is a myeloproliferative neoplasm.
- Leukemic infiltration of bone can cause pain.
- Neurological complications in CGL are not well-documented.
Purpose of the Study:
- To investigate the significance of sciatica and back pain in CGL patients.
- To determine if these symptoms are associated with disease progression.
Main Methods:
- Case series presentation of six CGL patients.
- Clinical observation of symptom development and disease course.
- Radiological and post-mortem examination for bony infiltration.
Main Results:
- All six patients developed sciatica and back pain.
- Other signs of accelerated CGL appeared within months.
- Radiological or post-mortem evidence of bony infiltration was found in four patients.
- All patients died, indicating a poor prognosis.
Conclusions:
- Sciatica and back pain may be indicative of accelerated CGL.
- These symptoms could herald the terminal stage of the disease.
- Leukemic bone infiltration is a potential cause of these symptoms.