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Toxicology reference data for the Wistar rat

P J Lewi, R P Marsboom

    Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
    |January 1, 1982
    PubMed
    Summary

    This study compiled 16 years of Wistar rat data, including weights and clinical chemistry, from 3,400 control animals. Statistical charts detail variations for use as reference data in toxicology.

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    Area of Science:

    • Toxicology
    • Animal Science
    • Statistical Analysis

    Background:

    • Long-term toxicological studies require robust control data.
    • Wistar rats are a common model organism in preclinical research.
    • Establishing normative biological and physiological data is crucial for interpreting toxicity study results.

    Purpose of the Study:

    • To compile and analyze extensive control data from Wistar rats over 16 years.
    • To develop statistical charts for visualizing biological and physiological parameters.
    • To provide reference data for use in toxicological assessments.

    Main Methods:

    • Compilation of 66 observations from 3,400 Wistar rats.
    • Inclusion of body weights, organ weights, clinical biochemistry, hematology, and urinalysis data.
    • Statistical analysis to generate frequency and cumulative distributions, and variations by time, sex, and age.

    Main Results:

    • Detailed statistical charts were created, summarizing key parameters.
    • Distributions revealed variations based on observation time, rat sex, and age.
    • The data provides a comprehensive baseline for control Wistar rats.

    Conclusions:

    • The compiled data and statistical charts serve as valuable reference standards in toxicology.
    • Understanding variations in control animal data is essential for accurate toxicity evaluations.
    • This resource aids in the interpretation of toxicity study findings and enhances experimental design.

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