Lymphoplasmacyte infiltrate in cervical intraepithelial neoplasia grade III

The behaviour of the lymphoplasmacyte reaction, regarded as an immune defence reaction of the organism, has been evaluated in 167 patients affected by cervical intraepithelial neoplasia or by microcarcinoma. It was observed that in surely in situ forms (atypical metaplasia, severe dysplasia and carcinoma in situ) there is a clear prevalence of cases with a minimal or absent reaction, while in the potentially invasive carcinoma and in the microcarcinoma there is a predominance of cases with a marked reaction, as if the first biological modifications that lead to invasion were accompanied by a massive activation of the immune defence mechanisms. We finally noticed that no relation exists between the appearance of CIN-lesion recurrences and the intensity of the stromal reaction. This further confirms the hypothesis that in the first steps of the carcinogenic process exogenous causes are mainly involved.