Effect of aminoglutethimide on androgenic functions in mice

Administration of aminoglutethimide (EliptenR, CIBA) to intact and castrated male mice decreased the weight of seminal vesicles and kidneys of intact males. However, the effect was not additive to that of orchietomy. Testicular cholesterol and protein content was significantly increased by aminoglutethimide, whereas no significant changes in testicular weight and blood testosterone were found, both being only moderately decreased.