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Polyclonal B-cell activity in myasthenia gravis

A I Levinson, A Dziarski, R P Lisak

    Neurology
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Some myasthenia gravis patients show increased immunoglobulin secreting cells (IgSC), indicating potential in vivo B-cell activation. This finding was independent of treatment or disease duration, but linked to active symptoms.

    Area of Science:

    • Immunology
    • Neurology
    • Autoimmune Diseases

    Background:

    • Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions.
    • The role of B-cell activation in MG pathogenesis requires further elucidation.

    Purpose of the Study:

    • To investigate the levels of circulating immunoglobulin secreting cells (IgSC) in patients with myasthenia gravis.
    • To explore the relationship between IgSC levels and clinical parameters in MG.

    Main Methods:

    • Utilized a protein A-reverse hemolytic plaque assay to quantify IgSC.
    • Assessed peripheral blood mononuclear cell responses to pokeweed mitogen in vitro.

    Main Results:

    • Elevated IgSC numbers were observed in a subset of myasthenia gravis patients.

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  • Increased IgSC levels correlated with active disease symptoms but not with drug therapy, age, sex, symptom duration, thymectomy, or AChR antibody levels.
  • In vitro B-cell activation responses to pokeweed mitogen were normal.

    • Conclusions:

    • Suggests increased in vivo polyclonal B-cell activation in some myasthenia gravis patients.
    • Highlights a potential immune dysregulation distinct from in vitro findings.