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Updated: Aug 9, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

Derivation of human T-cell leukemias

E L Reinherz, S F Schlossman

    Cancer Research
    |November 1, 1981
    PubMed

    Cell surface antigenic changes occur during the stages of T-cell ontogeny in several animal model systems. In the present study, multiple monoclonal antibodies were developed to human thymocyte and T-cell surface differentiation antigens as a means of probing T-cell ontogeny in humans. It was shown that three distinct states of human intrathymic differentiation exist and that the mature inducer (T4+) and suppressor (T5+/TH2+)T-cell subsets arise at specific points during these maturation events. Moreover, T-cell leukemias can now be related to the three stages of the thymic compartment or, alternatively, the more differentiated peripheral T-cell compartment.

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