[Cellular composition of different zones in the rat and rabbit hepatic lobule under normal and experimental...

Different types of hepatocytes (with caryopycnosis and caryolysis, at the state of mitosis, with amitotic nuclear strangulation and with two nuclei) were counted in the central, middle and peripheral zones of the hepatic lobule in rats subjected to an acute aminosin intoxication, and in rabbits after compressing soft tissues of the extremities. Time of observation--1--90 days in the rats and 10 h--20 days in the rabbits. In the zones of the hepatic lobule with the greatest degree of damage, the number of cells with caryopycnosis and caryolysis, as well as the number of hepatocytes with amitotic nuclear strangulation and binucleated cells were especially great. Mitotic activity of the hepatic cells was about 0.49% in the rats and 0.07% in the rabbits. Regardless the place of the damage in the hepatic lobule in all the zones, there was a definite correlation between the amount of cellular forms reflecting the demage and destruction of hepatocytes and their restoration, the same as observed in certain zones of the intact hepatic lobule.