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Cyclic hematopoiesis: etiological concepts. Clinical research update
The American Journal of Pediatric Hematology/Oncology
|January 1, 1982
Summary
Cyclic neutropenia and canine cyclic hematopoiesis show regular oscillations in blood cell counts, indicating a failure in regulatory control mechanisms. Understanding these cycles is key to comprehending blood cell regulation.
Area of Science:
- Hematology
- Cellular Biology
- Animal Models
Background:
- Normal blood cell counts are maintained in a steady state.
- Cyclic neutropenia in humans and canine cyclic hematopoiesis exhibit regular oscillations in blood elements.
- These cycles suggest a failure in regulatory control.
Purpose of the Study:
- To review current concepts on the etiologies of cyclic hematopoiesis.
- To enhance the understanding of normal and abnormal blood cell regulatory mechanisms.
Main Methods:
- Literature review of current concepts.
- Analysis of cyclic hematopoiesis in human and canine models.
Main Results:
- Cyclic hematopoiesis is characterized by clocklike precision in oscillations.
- The precise nature of the cycles points to a significant regulatory control failure.
Conclusions:
- Understanding the pathogenesis of cyclic hematopoiesis is crucial.
- Further research into regulatory mechanisms can elucidate normal and abnormal hematopoiesis.