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Benoxaprofen--dose-range studies using quantitative thermography

P A Bacon, J Davies, F J Ring

    The Journal of Rheumatology. Supplement
    |January 1, 1980
    PubMed
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    Benoxaprofen demonstrated analgesic effects in rheumatoid arthritis patients at all tested doses. At 600 mg daily, it also showed significant anti-inflammatory benefits, comparable to indomethacin, with no observed side effects.

    Area of Science:

    • Rheumatology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Rheumatoid arthritis (RA) is a chronic inflammatory disease.
    • Effective pain management and inflammation reduction are key goals in RA treatment.

    Purpose of the Study:

    • To evaluate the analgesic and anti-inflammatory effects of benoxaprofen in hospitalized rheumatoid arthritis patients.
    • To compare benoxaprofen's efficacy and safety against placebo and indomethacin.

    Main Methods:

    • A dose-range study comparing benoxaprofen with placebo.
    • A comparative study of benoxaprofen and indomethacin.
    • Patient assessments included pain, function, analgesic consumption, and computerized thermography.
    • Studies involved 54 hospitalized RA patients over a 3-week period post-washout.

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    Main Results:

    • Benoxaprofen exhibited analgesic activity across all evaluated dose levels.
    • A daily dosage of 600 mg benoxaprofen demonstrated significant anti-inflammatory effects.
    • Computerized thermography confirmed benoxaprofen's anti-inflammatory action, validated by comparison with indomethacin.
    • Clinical improvement observed in all groups was attributed to hospitalization and bed rest.

    Conclusions:

    • Benoxaprofen possesses both analgesic and anti-inflammatory properties in rheumatoid arthritis.
    • The drug is effective at a 600 mg daily dose, showing comparable anti-inflammatory effects to indomethacin.
    • Benoxaprofen was well-tolerated, with no adverse effects reported during the study.