Benoxaprofen administered once a day: determination of optimum dosage schedule

Six centers participated in a double-blind crossover study in patients with rheumatoid arthritis (RA) and osteoarthritis to evaluate the most advantageous timing of the daily dose of benoxaprofen. The study results revealed no significant difference between the morning and evening dose administered at a daily dose of 600 mg; however, more patients with RA preferred the evening dose.