Toxic nephropathy from diagnostic and therapeutic agents. Review and commentary

Drugs commonly used for diagnostic and therapeutic purposes may cause toxic nephropathy. There are several factors that account for renal susceptibility. Precise mechanisms of toxicity are generally not known, and therapy depends upon recognizing and removing the offending agent. Drugs that affect identifiable segments of the nephron or that produce similar syndromes are grouped together. Measures that might prevent toxicity are presented.