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Acid-induced gastric inhibitory polypeptide secretion in man
The Journal of Clinical Endocrinology and Metabolism
|December 1, 1980
Summary
Hydrochloric acid (HCl) stimulates gastric inhibitory polypeptide (GIP) secretion, particularly when combined with glucose intraduodenally. The physiological significance of this acid-induced GIP release requires further investigation.
Area of Science:
- Gastroenterology
- Endocrinology
- Metabolic Research
Background:
- Gastric inhibitory polypeptide (GIP) plays a crucial role in glucose metabolism and insulin secretion.
- The influence of intraduodenal acid on GIP and insulin release is not fully understood.
Purpose of the Study:
- To investigate the effects of oral and intraduodenal hydrochloric acid (HCl), alone and with glucose, on GIP and insulin secretion.
- To compare the responses to oral versus intraduodenal administration.
Main Methods:
- Eight healthy young males participated in oral tests with glucose, HCl, or a glucose-acid combination.
- A control group of eight received intraduodenal infusions of glucose, HCl, or their combination.
- Tests were conducted randomly at weekly intervals, measuring GIP and insulin levels.
Main Results:
- HCl alone stimulated GIP secretion, though less potently and with a delay compared to glucose.
- Oral or intraduodenal glucose with HCl showed similar peak insulin and GIP responses.
- Intraduodenal acid potentiated both GIP and insulin responses when co-administered with glucose, an effect not seen with oral administration.
Conclusions:
- Hydrochloric acid independently stimulates GIP secretion.
- The potentiation of GIP and insulin secretion by intraduodenal acid and glucose suggests a potential interaction, but its physiological relevance needs further study.