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Age, Estrogens, and the psyche

C B Coulam

    Clinical Obstetrics and Gynecology
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Menopausal psychological changes, including anxiety and depression, are influenced by aging and stress. Estrogen deficiency can worsen these symptoms, but hormone therapy is only recommended if other treatments fail.

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    Area of Science:

    • Reproductive endocrinology
    • Neuropsychology
    • Gerontology

    Background:

    • Menopause is associated with estrogen deficiency, leading to physical symptoms like hot flushes.
    • Psychological changes, including anxiety and depression, are also common during menopause.
    • Both aging physiology and environmental stressors contribute to these psychological symptoms.

    Purpose of the Study:

    • To review the psychological aspects of the menopausal syndrome.
    • To understand the contributing factors to psychological changes during menopause.
    • To establish therapeutic principles for managing menopausal psychological symptoms.

    Main Methods:

    • Literature review on menopause, estrogen deficiency, and psychological changes.
    • Analysis of the interplay between aging, stress, and hormonal factors.

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  • Evaluation of treatment strategies for menopausal psychological symptoms.

    • Main Results:

    • Estrogen deficiency can exacerbate psychological symptoms like anxiety and depression.
    • Central nervous system mediators, including catecholamines and prostaglandins, are involved in estrogen's effect.
    • Psychological symptoms at menopause are multifactorial, involving aging, stress, and hormonal influences.

    Conclusions:

    • Psychological symptoms of menopause should initially be treated as general anxiety or depressive reactions.
    • Replacement hormone therapy should be considered only when other treatments are ineffective and estrogen deficiency is clearly predominant.
    • A comprehensive approach addressing psychological and physiological factors is crucial for managing the menopausal syndrome.