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Clinical experience with 99mTc-disofenin as a cholescintigraphic agent
Radiology
|September 1, 1981
Summary
Technetium-99m-disofenin (99mTc-disofenin) provides excellent hepatobiliary imaging for diagnosing acute cholecystitis, even in jaundiced patients. This agent shows rapid blood clearance and minimal renal interference, ensuring clear visualization of the biliary system.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Hepatobiliary Imaging
Background:
- Iminodiacetic acid derivatives are crucial in nuclear medicine for hepatobiliary studies.
- Accurate imaging of the hepatobiliary system is essential for diagnosing conditions like cholecystitis.
Purpose of the Study:
- To evaluate the efficacy of 99mTc-disofenin for cholescintigraphy.
- To assess the diagnostic performance of 99mTc-disofenin in patients with hepatobiliary disease, including those with jaundice.
Main Methods:
- Cholescintigraphy was performed using 99mTc-disofenin in 6 healthy volunteers and 82 patients.
- Blood and urine clearance were assessed.
- Diagnostic accuracy for acute cholecystitis and biliary tract normality was evaluated.
Main Results:
- 99mTc-disofenin demonstrated rapid blood clearance by hepatocytes, enabling satisfactory to excellent hepatobiliary images.
- Renal activity interference was minimal (11%).
- Acute cholecystitis was correctly diagnosed in 20 patients, including 9 with jaundice (bilirubin 1.2-7.6 mg/dl). 60% of jaundiced patients had normal biliary tracts.
Conclusions:
- 99mTc-disofenin is a highly effective agent for hepatobiliary scintigraphy.
- Its rapid hepatocyte uptake and minimal renal interference facilitate clear imaging.
- The agent is valuable for diagnosing acute cholecystitis, even in the presence of jaundice.