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Post-translational carboxylation of preprothrombin
Molecular and Cellular Biochemistry
|August 11, 1981
Summary
This review covers vitamin K
Area of Science:
- Biochemistry
- Molecular Biology
Background:
- Vitamin K is essential for post-translational modification of proteins.
- This process involves the carboxylation of glutamyl residues.
Purpose of the Study:
- To review recent advancements in vitamin K-dependent carboxylation.
- To discuss the enzymes, mechanisms, and vitamin K's role in this reaction.
Main Methods:
- Review of recent literature on vitamin K function and carboxylation.
- Analysis of vitamin K analogs, antagonists, and exogenous substrates.
- Description of known vitamin K-dependent gamma-carboxyglutamic acid (Gla)-containing proteins.
Main Results:
- Detailed examination of the carboxylation reaction, its enzymes, and mechanisms.
- Exploration of vitamin K's metabolic relationship to carboxylation.
- Overview of various vitamin K-dependent Gla-proteins.
Conclusions:
- The review consolidates current understanding of vitamin K's role in protein carboxylation.
- It highlights the significance of this modification for protein function.