Related Experiment Videos
[Immunosorption on active carbon]
Voprosy Meditsinskoi Khimii
|January 1, 1981
Summary
Haemosorption for autoimmune diseases primarily removes Immunoglobulin G, not significantly altering overall immunoglobulin levels. Optimal carbon haemosorbents for blood purification depend on transient pore volume for effective protein removal.
Area of Science:
- Biochemistry
- Materials Science
- Immunology
Background:
- Haemosorption is a therapeutic process used in autoimmune diseases.
- The primary mechanism is thought to involve the removal of specific immunoglobulins.
- Previous studies suggested altered immunoglobulin levels post-haemosorption, but this was not consistently observed.
Purpose of the Study:
- To investigate the specific proteins removed during haemosorption in psoriasis patients.
- To determine the relationship between haemosorbent properties and protein sorption capacity.
- To optimize the design of active carbons for enhanced blood purification.
Main Methods:
- Biochemical blood analyses of psoriasis patients before and after haemosorption.
- Protein spectrum determination using immunized rabbits and carbon suspension from patient blood.
- Model experiments to study albumin sorption and correlate it with carbon pore structure.
Main Results:
- Haemosorption did not significantly alter overall immunoglobulin content in psoriasis patients.
- Immunoglobulin G was identified as the primary protein component absorbed by haemosorbents.
- Active carbon's protein sorption capacity was directly dependent on its transient pore volume.
Conclusions:
- The detoxicating effect of haemosorption in autoimmune diseases may involve specific immunoglobulin removal, particularly Immunoglobulin G.
- Active carbon haemosorbents can be synthesized with optimized transient pore volumes for improved efficiency in removing protein components from blood plasma.
- This research provides recommendations for developing more effective blood purification materials.