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Does verapamil influence glucose-induced insulin release in man?
Acta Medica Scandinavica
|January 1, 1981
Summary
Verapamil did not alter oral glucose tolerance or insulin release in patients. This study found that intravenous verapamil does not affect glucose absorption or pancreatic insulin secretion in individuals with normal blood sugar levels.
Area of Science:
- Endocrinology
- Pharmacology
- Gastroenterology
Background:
- Verapamil is a calcium channel blocker with potential effects on glucose metabolism.
- Understanding verapamil's impact on glucose and insulin regulation is crucial for patient management.
Purpose of the Study:
- To investigate the effect of intravenous verapamil on oral glucose tolerance.
- To assess verapamil's influence on pancreatic insulin release in response to oral glucose.
Main Methods:
- A study involving 6 normoglycemic patients with abdominal diseases.
- Each patient underwent two testing sessions: one with oral glucose plus intravenous verapamil, and another with oral glucose plus intravenous saline.
- Blood samples were collected from both portal and antecubital veins to measure glucose and insulin levels.
Main Results:
- Intravenous verapamil administration did not significantly change blood glucose levels after oral glucose ingestion.
- Serum insulin responses to oral glucose were unaffected by verapamil in both portal and peripheral venous blood.
- No significant alterations in glucose tolerance or insulin secretion were observed.
Conclusions:
- Intravenous verapamil does not impact oral glucose tolerance in normoglycemic individuals.
- Pancreatic insulin release remains unaffected by intravenous verapamil administration.
- Intestinal glucose absorption is not influenced by intravenous verapamil in this patient group.