Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Placental toxicology

D R Goodman, R C James, R D Harbison

    Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence-based causation in toxicology: A 10-year retrospective.

    Human & experimental toxicology·2015
    Same author

    The assessment of an in-vitro model for evaluating the role of PARP in ethanol-mediated hepatotoxicity.

    International journal of critical illness and injury science·2015
    Same author

    Comments on recent discussions providing differing causation methodologies.

    Human & experimental toxicology·2013
    Same author

    Clear path: towards an evidence-based toxicology (EBT).

    Human & experimental toxicology·2009
    Same author

    Alpha1-adrenergic receptors and their significance to chemical-induced nephrotoxicity--a brief review.

    Research communications in molecular pathology and pharmacology·2002
    Same author

    Comparison of base-excision repair capacity in proliferating and differentiated PC 12 cells following acute challenge with dieldrin.

    Free radical biology & medicine·2001
    Same journal

    Preclinical Toxicological Evaluation of 7-Methoxy-3-Phenyl-4H-Chromen-4-one: Acute and Sub-acute Oral Toxicity with Histopathological Correlation.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Redox-dependent cytoprotection by zerumbone via Nrf2-Keap1 mediated restoration of antioxidant and apoptotic balance in Mancozeb-exposed cells.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Dihydroberberine in Metabolic Disorders: Bioavailability, Molecular Mechanisms, Toxicology, and Future Perspectives.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    RIFM fragrance ingredient safety assessment, linoleic acid, CAS Registry Number 60-33-3.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    ORGAN-SPECIFIC RESPONSES OF AGE-DEPENDENT VULNERABILITY TO DEOXYNIVALENOL IN FEMALE MICE.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Update to RIFM fragrance ingredient safety assessment, β-naphthyl isobutyl ether, CAS Registry Number 2173-57-1.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    See all related articles

    The placenta can be harmed by chemicals and drugs, potentially causing birth defects. More research is needed to understand drug-induced placental toxicity and its role in teratogenesis.

    Area of Science:

    • Toxicology
    • Developmental Biology
    • Obstetrics

    Background:

    • The placenta is a critical organ for fetal development.
    • Chemicals and drugs can impact placental function.
    • Placental dysfunction is linked to adverse pregnancy outcomes.

    Purpose of the Study:

    • To review the literature on the placenta as a target organ for chemical- and drug-induced injuries.
    • To explore mechanisms by which xenobiotics can cause placental damage.
    • To highlight the need for further research in this area.

    Main Methods:

    • Literature review of scientific articles.
    • Analysis of studies on xenobiotic effects on placental function.
    • Synthesis of information on teratogenesis and reproductive defects.

    Related Experiment Videos

    Main Results:

    • Xenobiotics can injure the placenta by affecting transport, blood flow, or causing pathology.
    • Placental metabolism of xenobiotics can produce harmful substances.
    • Xenobiotics can alter placental endocrine function, impacting fetal development.

    Conclusions:

    • Drug- or chemical-induced placental toxicity is a plausible mechanism for teratogenicity.
    • This area of research has been comparatively neglected.
    • Extensive investigation into placental toxicity is warranted.