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[Latent bacterial carrier state and resistance to colonization after antibiotic therapy]
Abstract:
The enteral administration of antibiotics has been shown to induce the occult carriership (persistence) of sporulating Gram-positive bacilli inhabiting the intestine before the use of antibiotics and V. eltor introduced orally after the administration of antibiotics is stopped. After the prolonged use of some antibiotics the intestinal tract has been found to become an inadequate environment for the life of nonpathogenic E. coli easily colonizing the intestine of intact germ-free animals. Such form of resistance of colonization is an unfavorable consequence of antibiotic therapy.
Insights
Antibiotic use can lead to the persistence of certain gut bacteria and hinder the colonization of beneficial E. coli. This antibiotic-induced resistance impacts the intestinal environment and gut microbiome balance.
Area of Science:
- Microbiology
- Gastroenterology
- Pharmacology
Context:
- Antibiotic therapy can alter the gut microbiome composition.
- The intestinal tract's environment is susceptible to changes induced by antibiotics.
Purpose:
- To investigate the effects of enteral antibiotic administration on gut bacterial persistence.
- To examine the impact of antibiotics on the colonization resistance of the gut.
Summary:
- Enteral antibiotics can induce occult carriership of sporulating Gram-positive bacilli.
- Prolonged antibiotic use creates an environment unfavorable for nonpathogenic E. coli colonization.
- This results in a form of colonization resistance as an unfavorable consequence of antibiotic therapy.
Impact:
- Highlights potential disruptions to the gut microbiome from antibiotic treatment.
- Informs strategies for managing gut health during and after antibiotic therapy.
- Underscores the importance of understanding antibiotic-induced changes in intestinal ecology.