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Updated: Jul 17, 2026
07:24
Pseudomonas aeruginosa Induced Lung Injury Model
Published on: October 29, 2014
Summary
This study details the first documented case of severe D-penicillamine-induced pneumonitis in a rheumatoid arthritis patient. Histological analysis revealed significant lung damage, prompting a review of the drug
Area of Science:
- Pulmonology
- Rheumatology
- Pharmacology
Background:
- Rheumatoid arthritis (RA) treatment often involves disease-modifying antirheumatic drugs (DMARDs).
- D-penicillamine is a DMARD used for RA, known for potential adverse effects.
- Gold salts are an alternative RA treatment, and intolerance to gold was noted in this patient.
Observation:
- A 73-year-old woman with RA and prior gold intolerance developed severe respiratory symptoms.
- Histopathological examination of lung tissue showed extensive interstitial and alveolar damage.
- The observed lung damage pattern was similar to that seen with certain chemotherapy agents.
Findings:
- This case represents the first histological description of severe D-penicillamine-induced pneumonitis.
- The pathological findings indicate significant drug-induced lung injury.
- The patient's history of gold intolerance may be relevant to drug-induced hypersensitivity.
Implications:
- This case highlights the potential for severe pulmonary toxicity with D-penicillamine.
- Understanding the pathogenetic pathways of D-penicillamine pneumonitis is crucial for patient management.
- Careful monitoring and consideration of alternative treatments are recommended for patients on D-penicillamine, especially those with a history of drug intolerance.
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