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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Related Experiment Video

Updated: Dec 27, 2025

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Acute severe asthma treated without steroids

A R Luksza

    British Journal of Diseases of the Chest
    |January 1, 1982
    PubMed
    Summary

    This study questions the value of steroids in treating acute severe asthma. Results showed similar recovery times and lung function improvements across different steroid dosages, suggesting further research is needed.

    Area of Science:

    • Pulmonology
    • Clinical Medicine
    • Pharmacology

    Background:

    • Acute severe asthma requires effective treatment strategies.
    • The role of corticosteroids in managing severe asthma attacks is debated.
    • Conventional asthma management often includes steroid therapy.

    Purpose of the Study:

    • To investigate the efficacy of varying hydrocortisone doses in acute severe asthma.
    • To compare treatment outcomes between patients receiving no steroids, low-dose steroids, and high-dose steroids.
    • To evaluate the clinical impact of steroid use on asthma exacerbations.

    Main Methods:

    • A comparative study involving 90 patients with acute severe asthma.
    • Three treatment groups: no systemic steroids, 400 mg hydrocortisone daily, and 1200 mg hydrocortisone daily.

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  • Monitoring of recovery time, heart rate, and peak expiratory flow rate (PEFR).

    • Main Results:

    • All patients recovered from their asthma attacks.
    • No significant differences were observed in recovery time, heart rate, or PEFR between groups.
    • Low-dose and high-dose hydrocortisone showed similar outcomes to no steroid treatment.

    Conclusions:

    • The current findings suggest corticosteroids may have doubtful value in treating acute severe asthma.
    • Further randomized controlled trials are necessary to definitively establish the role of steroids.
    • Evidence indicates a need to re-evaluate standard steroid treatment protocols for severe asthma.