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Prevalence of penicillin-resistant pneumococci in Houston, Texas
Abstract:
Pneumococci resistant to penicillin have been reported in increasing numbers world-wide. A survey for resistance to penicillin G in 222 clinical isolates taken from patients in Houston is reported here. Thirteen (5.9%) of the isolates screened exhibited moderate levels of resistance with MIC's ranging from 0.125-0.5 microgram/ml. The authors recommend routine screening for pneumococcal resistance in isolates from blood, cerebrospinal fluid and tissue exudates.
Insights
Penicillin-resistant Streptococcus pneumoniae (pneumococci) are increasing globally. A Houston study found 5.9% of clinical isolates showed moderate penicillin resistance, recommending routine screening for this common pathogen.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Increasing global reports of penicillin-resistant Streptococcus pneumoniae (pneumococci).
- Penicillin resistance poses a significant threat to treating pneumococcal infections.
Purpose of the Study:
- To survey the prevalence of penicillin G resistance in clinical pneumococcal isolates in Houston.
- To assess the levels of resistance in identified resistant strains.
Main Methods:
- Screening of 222 clinical isolates of Streptococcus pneumoniae.
- Determination of Minimum Inhibitory Concentrations (MICs) for penicillin G.
Main Results:
- Thirteen isolates (5.9%) exhibited moderate penicillin resistance.
- MICs for resistant isolates ranged from 0.125 to 0.5 microgram/ml.
Conclusions:
- Penicillin resistance in pneumococci is present in Houston clinical isolates.
- Routine screening for pneumococcal resistance is recommended for blood, cerebrospinal fluid, and tissue exudates.