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Effect of surgery on monocyte function

M Oladimeji, A D Grimshaw, M Baum

    The British Journal of Surgery
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Surgery impacts immune cells, increasing in vitro monocyte lysozyme production (IVMLP) and peripheral monocyte counts post-operation. These changes in mononuclear phagocytes may affect wound healing.

    Area of Science:

    • Immunology
    • Surgical Science

    Background:

    • Mononuclear phagocytes play a crucial role in immune responses and tissue repair.
    • Understanding their behavior after surgical stress is important for optimizing patient recovery.

    Purpose of the Study:

    • To investigate the effects of surgery on monocyte function and count.
    • To assess changes in in vitro monocyte lysozyme production (IVMLP) and peripheral monocyte counts following surgical procedures.

    Main Methods:

    • Assessed IVMLP in 10 male patients preoperatively and postoperatively.
    • Monitored IVMLP in 6 matched controls.
    • Utilized a Technicon Hemalog D counter for accurate peripheral monocyte counts in patients and controls.

    Main Results:

    Related Experiment Videos

  • Surgical patients exhibited a significant increase in IVMLP at 6-10 hours postoperatively, returning to baseline by 10 days.
  • Peripheral monocyte counts were elevated in surgical patients at 36-48 hours and persisted for up to 10 days.
  • Control groups showed stable IVMLP and monocyte counts throughout the study period.

    • Conclusions:

    • Surgery induces both qualitative (IVMLP) and quantitative (monocyte counts) changes in mononuclear phagocytes.
    • These alterations in monocyte behavior may influence the early stages of wound healing.