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Pattern evoked cortical potentials and compressive lesions along the visual pathways

G H van Lith, S Vijfvinkel-Bruinenga, H Graniewski-Wijnands

    Documenta Ophthalmologica. Advances in Ophthalmology
    |January 29, 1982
    PubMed
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    Compressive lesions on the anterior visual pathways, not just demyelinating diseases, can disrupt occipital potentials. Tumors pressing on optic nerve fibers, particularly those near the optic nerve or chiasm, cause significant pattern response disturbances.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Neurology

    Background:

    • Demyelinating diseases and compressive lesions can affect visual pathway function.
    • Pattern electroretinography (PERG) and visual evoked potentials (VEPs) are used to assess visual pathway integrity.
    • Distinguishing between different types of visual pathway pathologies is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the impact of compressive lesions on the anterior visual pathways on occipital potentials.
    • To differentiate the effects of compressive lesions from demyelinating diseases on pattern reversal stimulation responses.
    • To identify the specific locations of tumors that cause significant disturbances in pattern visual evoked potentials (pVEPs).

    Main Methods:

    • Analysis of occipital potentials in response to pattern reversal stimulation.

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  • Evaluation of patients with suspected lesions along the anterior visual pathways.
  • Correlation of electrophysiological findings with tumor location and characteristics.

    • Main Results:

    • Compressive lesions, in addition to demyelinating diseases, can cause severely disturbed or delayed occipital potentials.
    • Tumors exerting significant pressure on optic nerve fibers lead to marked disturbances in pattern responses.
    • Tumors of the optic nerve, optic canal, anterior fossa base, or around the chiasm were associated with these disturbances.
    • Tumors of the orbit or those situated beyond the chiasm did not cause similar marked disturbances.

    Conclusions:

    • Compressive lesions in the anterior visual pathways are a significant cause of abnormal occipital potentials.
    • The location and pressure exerted by tumors are critical factors in the severity of visual pathway dysfunction.
    • Pattern visual evoked potentials can help localize compressive lesions affecting the anterior visual pathways, distinguishing them from other pathologies.