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Related Experiment Videos

The kidney and pregnancy

J P Harris, A C Chester, G E Schreiner

    American Family Physician
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Pregnancy significantly alters kidney function, leading to changes in clinical parameters and biochemical values. What is considered abnormal in non-pregnant individuals may be normal during pregnancy.

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    Area of Science:

    • Nephrology
    • Obstetrics
    • Physiology

    Background:

    • Pregnancy induces profound physiological changes in the maternal kidney.
    • Understanding these adaptations is crucial for accurate clinical assessment during gestation.

    Purpose of the Study:

    • To outline the typical alterations in renal function and related clinical parameters during pregnancy.
    • To highlight the concept that 'normal' values differ significantly between pregnant and non-pregnant states.

    Main Methods:

    • Review of established physiological changes in the kidney during pregnancy.
    • Compilation of common clinical and biochemical parameter shifts observed in pregnant individuals.

    Main Results:

    • Key changes include hydronephrosis, decreased blood urea nitrogen (BUN) and uric acid levels, and increased prevalence of proteinuria and glycosuria.

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  • Other common findings are urinary frequency, nocturia, edema, and altered blood pressure readings.
  • A BUN of 20 mg/dL in pregnancy is equivalent to 40 mg/dL in non-pregnant women; blood pressure of 120/80 mmHg at 24 weeks may indicate hypertension.

    • Conclusions:

    • Renal function undergoes significant, predictable modifications throughout pregnancy.
    • Clinical interpretation of laboratory values and vital signs must account for gestational status to avoid misdiagnosis.