[Measurement of dimensional distribution of plasma lipoproteins in human blood]

Possible application of optical mixing method to the investigations of distribution of lipoprotein (LP) particles according to their dimensions is shown. Sensitivity of the method for discovering changes in these distributions at the incubation of lipoprotein particles under different conditions was revealed. It has been shown in particular that when incubating low density lipoproteins (LDL) with erythrocytes the donor properties of LDL in relation to cholesterol, and when incubating high density lipoproteins (HDL) with these cells a more complicated picture is observed. HDL isolated from hypercholesterolemic plasma show the donor properties, and those isolated from the plasma with normal cholesterol level--the acceptor ones. In both cases a high level of aggregatability for total HDL fraction is observed.