2,3-diphosphoglycerate in high- and low-altitude populations of the deer mouse

Erythrocyte DPG concentrations were studied in populations of Peromyscus maniculatus native to different altitudes. Deer mice native to, and resident at, high altitude showed higher DPG/Hb ratios than did deer mice native to, and resident at, low altitude. However, after prolonged acclimation to low altitude, the high-altitude natives showed lower DPG/Hb ratios than did low-altitude natives. The differences in baseline DPG levels appear to be determined primarily by genetic factors. The heritability (h2) of DPG/Hb ratios was estimated by two independent methods to be 0.51 and 0.66, but those values are inflated to an unknown extent by environmental correlations between relatives. Mild cold stress did not elicit an increase in DPG/Hb ratios. DPG levels tended to decrease with age, but the aging effect was not consistently observed in all samples. Neither sex nor alpha-globin genotype influenced DPG levels. The adaptive significance of the genetic differences in DPG metabolism between high- and low-altitude populations remains problematic.