Catalytic role of some phenolic substances in endogenous formation of N-nitroso compounds

N-nitrosation can be catalysed or inhibited in vivo by different naturally-occurring polyphenolic compounds. The catalytic effect is particularly affected by pH. Thus, individual dietary habits can be expected to have marked effects on endogenous formation of N-nitroso compounds because of catalysis by polyphenols in foodstuffs, in addition to individual differences in pH.