Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poly-8-oxyinosinic acid

J O Folayan

    Journal of Biochemistry
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Poly(8-oxyinosinic acid) (poly O8I) hybrid with polycytidylic acid induces interferon production in mice brains. This novel hybrid demonstrated protective effects against Wesselsbron virus infection in vivo.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Synthesis and protective effects of poly-8-bromoriboadenylic acid: poly ribouridylic acid hybrid against Wesselsbron virus in chick embryos.

    Journal of biochemistry·1984
    Same author

    Synthesis and biological activity of polyriboadenylic acid: polyribo-5-dimethylaminouridylic acid hybrid (poly(A): poly(Me2N5U)).

    Journal of biochemistry·1983
    Same author

    Poly(A):poly(U); poly(O8A):poly(U); poly(A):poly(MeNH5U) and poly(O8A):poly(MeNH5U) versus Bida Semliki forest virus in chick embryos.

    Toxicology letters·1982
    Same author

    Partial purification and characterisation of bat liver ribonuclease. Hydrolysis of purine and pyrimidine polynucleotides by bat liver RNase.

    West African journal of pharmacology and drug research·1979
    Same author

    Effect of increasing doses of cephaloridine on rat urinary enzyme excretion.

    Nigerian medical journal : journal of the Nigeria Medical Association·1978
    Same author

    Poly(8-oxyadenylic acid).

    Biochimica et biophysica acta·1977
    Same journal

    Estrogen-related receptor γ functions as a novel corepressor of androgen receptor by destabilizing receptor conformation and blocking coactivator recruitment.

    Journal of biochemistry·2026
    Same journal

    Chromatin dynamics and cellular energy homeostasis.

    Journal of biochemistry·2026
    Same journal

    Nutrigenomic Regulation of One-Carbon Metabolism and the Circadian Clock in Health and Disease.

    Journal of biochemistry·2026
    Same journal

    Time to rethink circadian rhythms beyond the transcriptome.

    Journal of biochemistry·2026
    Same journal

    BNIP3/NIX-dependent mitophagy: molecular mechanisms and physiological roles.

    Journal of biochemistry·2026
    Same journal

    Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation.

    Journal of biochemistry·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Immunology
    • Virology

    Background:

    • Poly(8-oxyinosinic acid) (poly O8I) is a synthetic nucleic acid polymer.
    • Interferon induction and antiviral properties of synthetic polynucleotides are of significant interest.
    • Understanding the biological activity of novel polynucleotide hybrids is crucial for therapeutic development.

    Purpose of the Study:

    • To synthesize poly(8-oxyinosinic acid) (poly O8I).
    • To investigate the biological activity of a 1:1 hybrid formed between poly O8I and polycytidylic acid (poly C).
    • To assess the potential of this hybrid as an interferon inducer and antiviral agent.

    Main Methods:

    • Polymerization of 8-oxyinosine diphosphate using polynucleotide phosphorylase (PNPase) to synthesize poly O8I.

    Related Experiment Videos

  • Formation of a 1:1 hybrid complex between poly O8I and polycytidylic acid (poly C).
  • In vivo studies in white albino mice to evaluate interferon induction and protection against Wesselsbron virus.

    • Main Results:

    • Successful synthesis of poly O8I.
    • The poly O8I:poly C hybrid induced interferon production in the brains of treated mice.
    • Mice treated with the hybrid showed protection against Wesselsbron virus challenge.

    Conclusions:

    • The synthetic poly O8I:poly C hybrid exhibits potent interferon-inducing and antiviral activities in vivo.
    • This polynucleotide hybrid represents a promising candidate for further investigation as an antiviral therapeutic.
    • The study highlights the potential of synthetic nucleic acid analogs in modulating the immune response and combating viral infections.