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Congenital varicella zoster virus (VZV) infection can cause unilateral cataract and microphthalmos in infants. Maternal varicella during pregnancy is a risk factor for these ocular defects.
Area of Science:
- Ophthalmology
- Virology
- Teratology
Background:
- Varicella zoster virus (VZV) infection during pregnancy can lead to congenital abnormalities.
- Ocular manifestations of congenital VZV infection include cataracts and microphthalmos.
Observation:
- A 16-month-old boy presented with unilateral cataract and microphthalmos since birth.
- The patient exhibited elevated serum titers to VZV fluorescent membrane antigen (1:16 and 1:8).
- Maternal history revealed varicella infection during the fourth month of gestation.
Findings:
- The findings suggest a correlation between maternal VZV infection in early pregnancy and congenital ocular defects in the child.
- Elevated VZV titers in the infant support a diagnosis of congenital VZV syndrome.
Implications:
- Early diagnosis and management of congenital VZV infection are crucial for potential intervention.
- This case highlights the importance of considering maternal VZV exposure in the etiology of congenital ocular anomalies.
- Further research into the long-term visual outcomes and management strategies for congenital VZV-related ocular defects is warranted.
Abstract:
A 16-month-old boy with 1:16 and 1:8 serum titers to varicella zoster fluorescent membrane antigen had had unilateral cataract and microphthalmos since birth. The mother had suffered varicella during the fourth month of pregnancy. Cataract aspiration in the child was uncomplicated.