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Related Experiment Videos

Theophylline bioavailability in the dog

F L Tse, D W Szeto

    Journal of Pharmaceutical Sciences
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This study compared oral theophylline and aminophylline tablets and capsules to an intravenous standard in dogs. All oral theophylline formulations demonstrated complete bioavailability, though absorption rates varied.

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    Area of Science:

    • Pharmacokinetics
    • Drug bioavailability
    • Comparative drug analysis

    Background:

    • Theophylline is a bronchodilator used for respiratory diseases.
    • Understanding the bioavailability of different oral formulations is crucial for effective therapeutic use.
    • Previous studies have investigated theophylline pharmacokinetics, but direct comparisons of various oral forms are needed.

    Purpose of the Study:

    • To compare the bioavailability of oral theophylline and aminophylline formulations against an intravenous standard in beagle dogs.
    • To characterize the absorption kinetics of theophylline from different oral dosage forms.
    • To determine if oral theophylline products achieve complete systemic availability.

    Main Methods:

    • Single oral doses of theophylline capsule, theophylline tablet, and aminophylline tablet were administered to beagle dogs.

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  • An intravenous theophylline dose served as the reference standard.
  • Plasma theophylline concentrations were measured over time and analyzed using a one-compartment open model.

    • Main Results:

    • Theophylline absorption from all oral products was rapid.
    • The theophylline tablet exhibited a slower absorption rate compared to the theophylline capsule and aminophylline tablet.
    • All three oral formulations (theophylline capsule, theophylline tablet, aminophylline tablet) were found to be completely bioavailable relative to the intravenous standard.

    Conclusions:

    • Oral theophylline and aminophylline formulations are completely bioavailable in beagle dogs.
    • Dosage form influences the rate of theophylline absorption, with tablets potentially showing slower absorption than capsules.
    • These findings support the use of these oral theophylline products, with consideration for their absorption profiles.