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Updated: Aug 1, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
[Parameters of interaction of nitrophenols with different chemical structure with albumin, and their toxicity]
Abstract:
Chemical structure of a series of nitrophenols and their derivatives was studied in relation to their toxicity and complex-formation ability (association constant, amount of binding sites) with human blood serum albumin. Five compounds were studied using equilibrium dialysis and spectrofluorimetry. The nitrophenols, containing a hydrocarbon radical, exhibited distinctly higher affinity to albumin; substitution of one or two nitrogroups by aminogroups led to complete loss of the affinity to the protein. Dependence of acute toxicity on association constants of the complexes is discussed.
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