The dynamics of changes in the phosphorolytic and hydrolytic activity in the myocardium and skeletal muscle during adrenaline infusion
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Updated: Jul 29, 2026

Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice
Published on: September 17, 2015
Abstract:
Rats were given adrenaline in continuous intravenous infusion at a rate of 10 micrograms/kg/min for 5 and 8 minutes. The phosphorolytic and hydrolytic activity in the myocardium and skeletal muscle was determined by the method of simultaneous measurements at one-minute intervals. In the adrenalectomized rats the effect of the adrenaline-hydrocortisone interaction on these activities was investigated. The obtained results confirmed the validity of the hypothesis about a correlation between the changes in the amylolytic activity and the phosphorolytic activity, and demonstrated that this correlation was not changed by glycocorticosteroids. A significant temporal correlation was found between the dynamics of the mutually opposite changes in both these glycogenolytic activities. The hypothesis of a competition between amylolysis and glycogen phosporolysis is discussed assuming that this would help in the maintenance of a relative equilibrium between glycogen biosynthesis and breakdown.
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