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[New cerebrally active basic dithienyl compounds (author's tranls)]

K Thiele, K Posselt, H Offermanns

    Arzneimittel-Forschung
    |January 1, 1980
    PubMed
    Summary
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    This review covers new dithienyl compounds for brain activity, focusing on tinofedrine. Tinofedrine enhances cerebral blood flow, brain metabolism, and heart performance with good tolerability.

    Area of Science:

    • Medicinal Chemistry
    • Neuropharmacology

    Context:

    • Review of novel cerebrally active basic dithienyl compounds.
    • Focus on compounds structurally related to tinofedrine.

    Purpose:

    • To present new dithienyl compounds with potential therapeutic applications.
    • To discuss the synthesis routes for these compounds.

    Summary:

    • Tinofedrine, a selected dithienyl compound, demonstrates significant increases in cerebral blood flow.
    • It also improves heart performance and brain metabolism.
    • Tinofedrine exhibits good tolerability in preclinical assessments.

    Impact:

    • Highlights potential new drug candidates for cerebrovascular and neurological disorders.

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  • Provides insights into synthetic strategies for developing related therapeutic agents.