Sleep-wakefulness rhythms in mice after suprachiasmatic nucleus lesions

The experiment was performed in order to investigate whether the suprachiasmatic nucleus is a potent circadian pacemaker also in mice. Cortical EEG activity and neck muscle EMG were continuously recorded in 19 albino mice under 12 h light-12 h dark cycles. Computer analysis revealed that after bilateral suprachiasmatic nucleus (SCN) lesions, the diurnal rhythm in slow wave sleep (SWS) and paradoxical sleep (PS) stages was completely eliminated although ultradian rhythms with 2-4 h periodicity persisted. However, the daily amount of either slow wave sleep or paradoxical sleep did not show any significant change after small hypothalamic lesions with a complete destruction of SCN.