Mutagenic potential of cis-dichlorodiammine platinum II in rodents

The ability of cis-dichlorodiammine platinum II to cause chromosomal aberrations in rats and dominant lethality in mice was studied. Five daily intraperitoneal doses ranging from 0.25 to 2.00 mg/kg/day failed to result in the observance of dominant lethal mutations in mice. Intraperitoneal doses of 0.13 and 0.52 mg/kg/day for 5 days in rats did, however, cause chromosomal aberrations in bone marrow cells collected and harvested 24 h after the last dose. The incidence of total aberrations observed at the 0.52 mg/kg/day dose level was 5.5-fold greater than that seen for the vehicle control group. Thus, cis-dichlorodiammine platinum II appears to be clastogenic in rats.