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Updated: Aug 14, 2026

07:20
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Renal handling of cis-diamminedichloroplatinum(II)
Abstract:
The renal handling of cis-diamminedichloroplatinum(II) (cisplatin) was investigated by measuring the renal clearance of creatinine and free platinum (Pt). Free Pt clearance exceeded the glomerular filtration rate, indicating secretion of cisplatin or a metabolite. These results suggest that accumulation of Pt within renal tubular cells may be related to its nephrotoxicity.

