Granulomatous Torulopsis glabrata cholecystitis in a diabetic

A 53-year-old man who was a healthy, diet-controlled adult-onset diabetic underwent elective cholecystectomy eight weeks after an episode of acute cholecystitis. The gallbladder showed granulomatous inflammation and a single, mixed gallstone. Torulopsis glabrata was isolated from bile. This yeast of low pathogenicity is usually of clinical significance only in patients with serious associated illness. The patient remains well, and no reservoir for the organism has been identified in him. This is the first report of this organism causing cholecystitis confirmed by both culture and histologic examination. Supporting one report and conflicting with several others, the inflammatory reaction of T. glabrata may be granulomatous.