Related Experiment Video
Updated: Aug 9, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Stability of nonionic water-soluble contrast media: implications for their design
Abstract:
The stability of the nonionic contrast media metrizamide, P-297, iopamidol, and nonionic phenyl ether DS-1-132 was studied by exposing their aqueous solutions to 120 C. Metrizamide showed decomposition of the sugar residue, while in P-297 the sugar substituent was cleaved off the triiodoaniline moiety. Iopamidol and DS-1-132 showed no decomposition. For stability, sugar moieties should be attached either by an ether linkage or as amides, as long as the acylamino group is not on a carbon adjacent to the anomeric carbon. Polyhydroxyalkylamines are less hydrophilic but more stable than sugars.
More Related Videos
Related Concept Videos
Common Ion Effect
Factors Affecting Solubility
The Colloidal State
Radiological Investigation I: X-ray and CT
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

