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Related Experiment Videos

New media. Particulate contrast media

M R Violante, H W Fischer, J A Mahoney

    Investigative Radiology
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    New particulate contrast agents offer improved liver CT imaging by avoiding ionic imbalances. These agents accumulate in the liver, are cleared through the biliary system, and show promising results in animal studies.

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    Area of Science:

    • Radiology
    • Biomedical Engineering
    • Pharmacology

    Background:

    • Particulate contrast agents avoid hypertonicity and ionic imbalances common with water-soluble media.
    • Radiopaque particles accumulate in the reticuloendothelial system, making them suitable for hepatic CT contrast agents.

    Purpose of the Study:

    • To develop and evaluate novel particulate contrast agents for hepatic computed tomography (CT) imaging.
    • To overcome challenges of in vivo particle aggregation and embolization with particulate agents.

    Main Methods:

    • Developed 2 +/- 1 micron particles by organic solvent precipitation.
    • Preincubated particles in human serum albumin to prevent aggregation and embolization.
    • Administered ethyl esters of iothalamic and iodipamic acid intravenously to mice, rats, and rabbits.

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    Main Results:

    • Maximal liver radiopacification observed 2-3 hours post-infusion.
    • Radiopaque material cleared via the biliary system.
    • Complete elimination from the organism within a few days post-infusion.

    Conclusions:

    • Particulate contrast agents show potential for hepatic CT imaging.
    • Serum albumin preincubation effectively mitigates in vivo aggregation and embolization.
    • Further research is needed to reduce subacute toxicity.