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Amiodarone keratopathy

V Feiler-Ofry, M Lazar, A Solomon

    Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
    |January 1, 1980
    PubMed
    Summary
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    Amiodarone, a heart medication, can cause corneal deposits in patients. These deposits typically resolve without lasting vision problems, though blinking issues may worsen them.

    Area of Science:

    • Ophthalmology
    • Cardiology
    • Pharmacology

    Background:

    • Amiodarone is a widely used antiarrhythmic drug for cardiac conditions.
    • Corneal side effects are a known, though often reversible, complication of amiodarone therapy.

    Observation:

    • Six cardiac patients receiving systemic amiodarone treatment exhibited varying degrees of corneal involvement.
    • The observed corneal changes presented a specific clinical pattern consistent with amiodarone keratopathy.

    Findings:

    • The keratopathy associated with amiodarone demonstrated a generally benign clinical course.
    • Pathophysiological mechanisms underlying amiodarone-induced keratopathy were explored.
    • Factors such as lacrimal insufficiency and incomplete blinking appeared to exacerbate the severity of the corneal condition.

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    Implications:

    • Ophthalmologists should be aware of potential corneal side effects in patients treated with amiodarone.
    • Monitoring for and managing ocular symptoms is crucial for patients on long-term amiodarone therapy.
    • Understanding contributing factors like dry eye can aid in mitigating amiodarone keratopathy severity.