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[Cytur-test used in nephrology out-patients (author's transl)]
Insights
The Cytur-test, a rapid urine strip method, is not a replacement for traditional tests like the Addis count or urine sediment analysis in nephrology out-patients. While it can provide preliminary white cell information, it has limitations in sensitivity compared to established diagnostic techniques.
Area of Science:
- Clinical Chemistry
- Urology
- Nephrology
Context:
- Evaluating diagnostic tools for urinary white blood cell (leukocyte) detection.
- Assessing the utility of rapid urine test strips in clinical settings.
- Comparing novel rapid methods with established laboratory diagnostics for urine analysis.
Purpose:
- To determine the diagnostic value of the Cytur-test (urine test strips) for detecting white blood cells in out-patient urine samples.
- To compare the sensitivity and specificity of the Cytur-test against conventional methods like the Addis count and urine sediment examination.
- To ascertain if rapid urine test strips can serve as a substitute for standard urinalysis in nephrology out-patients.
Summary:
- The study evaluated 161 out-patient urine samples using the Cytur-test and compared results with the Addis count and urine sediment analysis.
- The Cytur-test showed a high percentage of negative results (84/88) in patients with no pathological leucocyturia according to conventional methods.
- Positive Cytur-test results in these cases (4/88) indicated lysed white cells. The test strip method yielded fewer positive findings (lower sensitivity) than Addis count (6/24) and urine sediment (2/11) due to its wider negative range.
Impact:
- The Cytur-test is not a substitute for conventional methods like Addis count or urine sediment analysis in hospital nephrology out-patients.
- Rapid urine test strips can offer preliminary information on urine white cell content.
- The findings highlight the limitations of rapid diagnostic tests in replacing established, more sensitive laboratory procedures for accurate urinary leukocyte assessment.
Abstract:
Assessment of the value of test strips for demonstration of white cells in urine (Cytur-test) in 161 out-patient urine samples showed that a quick method such as the Cytur-test is no substitute for conventional methods. In hospital nephrology out-patients methods such as the Addis count or the investigation of urine sediment cannot be replaced. However, in a preliminary test with test strips information can be obtained as to the white cell content of the urine. Samples from patients in whom Addis count or sediment results showed no pathological leucocyturia, also had negative results in the test strip in a high percentage (84 out of 88 cases). A positive Cytur-test indicates lysed white cells in such cases (4 out of 88 cases). Due to the different sensitivity, as a consequence of a wider negative range, the Cytur-test resulted in fewer positive findings when compared to the other methods: 6 out of 24 in the Addis count and 2 out of 11 in urinary sediment.