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Ascorbic acid and stress ulcer in the rat

G B Glavin, W P Paré, G P Vincent

    The Journal of Nutrition
    |December 1, 1978
    PubMed
    Summary
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    Ascorbic acid (vitamin C) did not protect rats from stomach ulcers caused by starvation or stress. In fact, high doses of ascorbic acid may have worsened ulcer development in these experimental models.

    Area of Science:

    • Gastroenterology
    • Nutritional Science
    • Pharmacology

    Background:

    • Stress and starvation are known risk factors for peptic ulcer disease.
    • Ascorbic acid (vitamin C) is a common dietary supplement with antioxidant properties.
    • Its potential role in preventing or exacerbating stress-induced ulcers requires investigation.

    Purpose of the Study:

    • To investigate the effect of ascorbic acid on experimentally induced gastric ulcers in rats.
    • To determine if ascorbic acid provides a protective effect against ulcers caused by starvation and various stress protocols.

    Main Methods:

    • Rats were subjected to different ulcerogenic conditions: total starvation, partial starvation, activity-stress, and restraint-cold stress.
    • Ascorbic acid was administered orally at a concentration of 30 g/liter to experimental groups.

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  • Ulcer formation was assessed in all experimental conditions.

    • Main Results:

    • Ascorbic acid administration did not significantly reduce the incidence or severity of gastric ulcers in any of the tested conditions.
    • In some experimental groups, ascorbic acid appeared to potentiate the ulcerogenic process, leading to more severe ulcers.
    • The findings were consistent across four separate experiments.

    Conclusions:

    • High-dose oral ascorbic acid does not offer protection against experimentally induced gastric ulcers in rats.
    • Ascorbic acid may potentially exacerbate ulcer formation under conditions of severe stress or starvation.
    • Further research is needed to elucidate the complex interaction between vitamin C and gastric mucosal integrity under duress.