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Selective transient suppression of globin chain synthesis by blood transfusions in beta-thalassemia

E C Zaino

    American Journal of Clinical Pathology
    |April 1, 1981
    PubMed

    Thalassemias are characterized by an imbalance in globin chain synthesis. When patients having beta-thalassemia major are given transfusions, globin synthesis is transiently suppressed, particularly the alpha chains. This results in a relatively improved alpha/beta ration that may erroneously be interpreted as indicating stimulation of beta chain synthesis.

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