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[Clinical picture and pathogenesis of generalized forms of herpes zoster]
Abstract:
Clinical examination of 83 patients with generalized herpes zoster has given the authors grounds to regard this disease as a result of activation of latent varicella-zoster virus. This assumption was confirmed by the results of indirect hemagglutination inhibition tests with 37 serum specimens taken from 18 patients. Treatment with antibiotics, the drug proper-myl, and by dehydration was the more effective, the earlier the patients were admitted to the clinic. Dehydration, proper-myl and combination of chloramphenicol with dehydration produced a more beneficial effect than the antibiotic alone. Five patients died. Problems of pathogenesis are discussed.
Insights
Generalized herpes zoster is linked to latent varicella-zoster virus reactivation. Early treatment with dehydration or proper-myl improved patient outcomes, though five deaths occurred.
Area of Science:
- Virology
- Immunology
- Clinical Medicine
Context:
- Generalized herpes zoster is a significant clinical presentation.
- Varicella-zoster virus (VZV) latency is a known phenomenon.
Purpose:
- To investigate the link between latent VZV reactivation and generalized herpes zoster.
- To evaluate the efficacy of different treatment modalities for generalized herpes zoster.
Summary:
- Clinical examination of 83 patients suggested generalized herpes zoster results from latent VZV activation.
- Indirect hemagglutination inhibition tests confirmed this association in 18 patients.
- Early treatment with antibiotics, proper-myl, or dehydration showed improved efficacy. Dehydration, proper-myl, and chloramphenicol with dehydration were more beneficial than antibiotics alone. Five fatalities were reported.
Impact:
- Provides evidence supporting VZV reactivation as the cause of generalized herpes zoster.
- Highlights the importance of early intervention in treating generalized herpes zoster.
- Informs clinical practice regarding effective treatment strategies for this condition.