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Massive ovarian oedema. Case report
British Journal of Obstetrics and Gynaecology
|May 1, 1981
Summary
Massive ovarian edema in a young girl caused secondary amenorrhea and masculinization. Surgical removal of ovarian tissue normalized testosterone levels and restored irregular ovulation.
Area of Science:
- Reproductive Endocrinology
- Gynecologic Pathology
Background:
- Massive ovarian edema is a rare condition characterized by excessive fluid accumulation within the ovarian stroma.
- It can present with symptoms mimicking androgen excess, including menstrual irregularities and signs of masculinization.
Observation:
- A case study of a young girl presenting with secondary amenorrhea and clinical evidence of masculinization.
- Markedly elevated peripheral plasma testosterone levels were noted pre-operatively.
Findings:
- Surgical wedge resection of both ovaries led to an immediate normalization of testosterone levels.
- Microscopic examination revealed lutein cells within atretic follicles in the right ovary and Stein-Leventhal-like features in the left ovary.
- Irregular ovulatory cycles resumed approximately four weeks post-surgery.
Implications:
- This case highlights massive ovarian edema as a potential cause of secondary amenorrhea and hyperandrogenism in young females.
- Surgical intervention, specifically wedge resection, can be effective in normalizing hormone levels and restoring ovulatory function.
- Understanding the histopathological features is crucial for accurate diagnosis and management of this rare condition.