Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rotary press utilizing a flexible die wall

G E Amidon, D P Smith, E N Hiestand

    Journal of Pharmaceutical Sciences
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Spatio-temporal patterns of prostate-specific antigen testing in asymptomatic men: a population-based cohort study, Australia, 2002-2018.

    Public health·2025
    Same author

    Spatial patterns of prostate-specific antigen testing in asymptomatic men across Australia: a population-based cohort study, 2017-2018.

    Public health·2023
    Same author

    Effect of Feeding a Postbiotic Derived from Saccharomyces cerevisiae Fermentation as a Preharvest Food Safety Hurdle for Reducing Salmonella Enteritidis in the Ceca of Layer Pullets.

    Journal of food protection·2020
    Same author

    Long-term unmet supportive care needs of prostate cancer survivors: 15-year follow-up from the NSW Prostate Cancer Care and Outcomes Study.

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2020
    Same author

    Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications.

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2019
    Same author

    Effect of elevated dietary inorganic zinc on live performance, carcass yield, and quality of male and female broilers.

    Poultry science·2018
    Same journal

    Immune tolerance platforms to mitigate unwanted immune responses.

    Journal of pharmaceutical sciences·2026
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    See all related articles

    A novel flexible die design significantly reduced tablet capping and fracture issues in challenging formulations. This innovation offers a promising solution for improving tablet manufacturing quality.

    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Tablet capping and fracture are common manufacturing defects, particularly with challenging formulations.
    • Conventional tablet dies can exert high residual stresses, contributing to these defects.

    Purpose of the Study:

    • To evaluate a novel flexible die design for tablet compression.
    • To assess the impact of reduced residual die wall pressure on tablet quality.

    Main Methods:

    • A flexible-walled die was designed and tested on a modified rotary tablet press.
    • Side compression roll forces during compression and decompression were monitored.
    • Three experimental formulations prone to capping were used for evaluation.

    Main Results:

    Related Experiment Videos

  • Tablets manufactured in a conventional die showed severe capping.
  • The flexible die significantly improved tablet quality for most formulations.
  • Adjusting compression forces allowed for the production of excellent tablets.

    • Conclusions:

    • The flexible die design effectively reduces residual die wall pressure.
    • This technology shows potential for improving tablet manufacturing, especially for problematic formulations.
    • Further engineering is needed for broader applicability in production equipment.