Chemical-enzymatic synthesis of biologically active DNA fragments

O G Chakhmakhcheva, V A Efimov, Ovchinnikov YuA

|January 1, 1980

Abstract:

In this communication we report our recent investigations concerned the design and construction of synthetic functionally active DNA fragments: the structural gene for pentapeptide Leu-enkephalin and the double-stranded 93 base pairs long polynucleotide representing the promoter region of bacteriophage fd DNA. The ways for synthesis of modified promoter analogs carrying photosensitive residues of 5-bromodeoxyuridine in different positions of the chain are also considered.

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Abstract:

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